Andrew West
Lead PI (Core Leadership)
Co-PI (Core Leadership)
Duke University
Dr. West is a tenured Professor of Pharmacology at Duke University with secondary appointments in Neurology and Neurobiology. He currently directs the Duke Center for Neurodegeneration and Neurotherapeutic Research.
Teams
Themes
Tags
Fibril
Gut-brain axis
Alpha-synuclein
Protein aggregates
Animal models
Pathology
Enteroendocrine cells
Proteomics
Cryo-EM
Seeding assays
Genetic variants
Genetic interactions
Cryo-ET
Genetic risk
Fluid-based biomarkers
Genomics
PD heterogeneity: alpha-synuclein seeding
Disease mechanisms
Recent ASAP Preprints & Published Papers
Lewy body diseases and the gut
Gastrointestinal (GI) involvement in Lewy body diseases (LBDs) has been observed since the initial descriptions of patients by James Parkinson. Recent experimental and human observational studies raise the possibility that pathogenic alpha-synuclein (⍺-syn) might develop in the GI tract and subsequently spread to susceptible brain regions. The cellular and mechanistic…
Mouse α-synuclein fibrils are structurally and functionally distinct from human fibrils associated with Lewy body diseases
The intricate process of α-synuclein aggregation and fibrillization hold pivotal roles in Parkinson’s disease (PD) and multiple system atrophy (MSA). While mouse α-synuclein can fibrillize in vitro, whether these fibrils commonly used in research to induce this process or form can reproduce structures in the human brain remains unknown. Here…
Team Koob
Team Liddle
Team West
Andrew West
Lead PI (Core Leadership)
Alberto Bartesaghi
Co-PI (Core Leadership)
Mario Borgnia
Co-PI (Core Leadership)
Lenora Higginbotham
Co-PI (Core Leadership)
Laura Volpicelli-Daley
Co-PI (Core Leadership)
Tuyana Malankhanova
Project Manager
Elizabeth Viverette
Project Manager, Trainee
David Bradway
Data Manager
