Background pattern of a brain with neural connections
Alberto Bartesaghi

Alberto Bartesaghi

Co-PI (Core Leadership)

Duke University

Alberto is an Associate Professor in the Departments of Computer Science, Biochemistry, and Electrical and Computer Engineering at Duke University. He is a pioneer in developing computational methods to solve structures of macromolecular complexes by single particle cryo-EM and cryo-ET. He solved many influential structures including those of CRISPR/Cas9 complexes, GPCR/G-protein complexes, HIV-1/SARS glyco-proteins, and α-synuclein fibers. He is also interested more broadly in machine learning, computer vision, image processing, and high-performance computing. He received the “Norman P. Salzman Memorial Award in Virology” from the Foundation for the National Institutes of Health, Bethesda, MD for his work on the molecular architecture of native HIV-1 gp120 trimers.

Teams

Themes

Tags

Fibril Alpha-synuclein Protein aggregates Pathology Proteomics Cryo-EM Seeding assays Cryo-ET Fluid-based biomarkers PD heterogeneity: alpha-synuclein seeding

Recent ASAP Preprints & Published Papers

This investigator is hard at work. Articles will be shared when they are available.

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Members of the CRN work diligently to advance our understanding of Parkinson’s disease. Learn more about recent CRN discoveries and achievements.