Background pattern of a brain with neural connections

Team Mackenzie

Defining functional heterogeneity within the subthalamic area and its relevance for psychiatric and cognitive symptoms of PD

2026-Present

Anxiety, depression, apathy, and cognitive deficits are debilitating symptoms in Parkinson’s disease (PD) and can be altered by deep brain stimulation (DBS) targeting the subthalamic nucleus (STN). This project examines STN and the adjacent parasubthalamic nucleus (pSTN) to better understand and treat these symptoms. We will link clinical data with mouse models to investigate how distinct STN and pSTN circuits impact mental health. Combining optogenetics, viral tracing, and physiological assessments, we will examine neuronal pathways and test whether selective manipulation mitigates dysfunction. The findings will help refine DBS techniques and pharmacological therapies to better address non-motor symptoms in PD patients.

Tags
Animal modelsDepressionDisease heterogeneityDisease modificationExercisein situ RNA analyticsLocus coeruleusNeurobiologyNeurodegenerationNon-motor symptomsOptogeneticsProdromal PD

Contributions

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Accolades

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In the News

$9M USD for safer treatment of psychiatric and cognitive symptoms in Parkinson’s disease

$9M USD for safer treatment of psychiatric and cognitive symptoms in Parkinson’s disease

05/12/2026 — A team of international researchers led by senior lecturer Åsa Mackenzie at Lund University has received a $9 million USD grant from the Aligning Science Across Parkinson’s (ASAP) initiative, in partnership with The Michael J Fox Foundation for Parkinson’s Research (MJFF), to advance understanding of Parkinson’s disease treatment, with a particular focus on depression, anxiety, and other psychiatric and cognitive symptoms, with the aim of informing more targeted treatment approaches.

Aligning Science Across Parkinson’s and The Michael J. Fox Foundation Expand Global Research Initiative with $261M Investment Toward Personalized Treatments

Aligning Science Across Parkinson’s and The Michael J. Fox Foundation Expand Global Research Initiative with $261M Investment Toward Personalized Treatments

04/28/2026 — Today, Aligning Science Across Parkinson’s (ASAP), in partnership with The Michael J. Fox Foundation for Parkinson’s Research (MJFF), announced $261 million in new grant funding for the Collaborative Research Network (CRN) to map the biological blueprint of Parkinson’s disease and build a standardized toolkit of global research resources that are needed to turn discoveries into treatments.

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