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Team Petrucelli
Identifying and Investigating Molecular Modifiers of Co-Pathologies in Parkinson’s Disease
Alpha-synuclein aggregation is the most prevalent pathology observed in Parkinson’s disease (PD) and PD dementia (PDD); however, many patients also present with inclusions composed of TAR DNA-binding protein 43 (TDP-43), amyloid beta, or tau. Such co-pathologies can have a profound impact on disease outcomes, and uncovering mechanisms that modulate co-pathologies in the brain could help guide therapeutic strategies for PD/PDD. We will use high-resolution molecular techniques to identify and examine modifiers of co-pathology presentation and ascertain the structural architecture underlying co pathologies in iNeurons and PD/PDD patient tissue. These studies will shed light on the pathomechanistic role of co-pathologies in PD/PDD.
Tags
Cryo-EMEndolysosomal dysfunctionGenetic susceptibilityiPSC neuronsProteomicsSpatial Transcriptomics
Our Research Teams
Members of the CRN work diligently to advance our understanding of Parkinson’s disease. Learn more about recent CRN discoveries and achievements.
