Yongjie Zhang

Dr. Zhang is an Associate Professor in the Department of Neuroscience at the Mayo Clinic Florida. His research focuses on the mechanisms and toxicity of abnormal protein aggregation, spatial neuropathology, and neuroimmune responses in neurodegenerative diseases, including FTD, ALS, AD, and PD. His work integrates mouse models, human postmortem brain tissue, and human iNeuron models to investigate how pathological proteins, particularly TDP-43, drive copathologies and adaptive immune responses. Ultimately, his research seeks to identify disease-relevant molecular and cellular mechanisms that can guide biomarker discovery and the development of targeted therapeutic strategies.