Background pattern of a brain with neural connections

Team Soto

Understanding alpha-synuclein seeding: Identification of cellular factors influencing seeding and structural and biological characterization of the SAA products

2026-Present

α-synuclein (αSyn) seeding is key for spreading Parkinson’s disease (PD) pathology throughout the brain. Recently, we developed the seed amplification assay (SAA) to reproduce αSyn seeding in vitro with high efficiency. SAA offers a great opportunity to detect αSyn seeds in human samples and to understand the disease biology. The main goal of this project is to understand αSyn seeding in the context of Parkinson’s disease, by identification of cellular factors modulating seeding, evaluating the nature of αSyn seeds detected by SAA in diverse tissues and fluid samples, and determining the structural and biological relevance of the SAA products.

Tags
Alpha-synucleinConformational strainsSeeding assays

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In the News

UTHealth Houston awarded nearly $8 million to research brain processes underlying Parkinson’s disease

UTHealth Houston awarded nearly $8 million to research brain processes underlying Parkinson’s disease

04/28/2026 — Researchers at UTHealth Houston have been awarded a three-year, $7.8 million grant from the Aligning Science Across Parkinson’s initiative to support projects that will help health professionals better understand how Parkinson’s disease occurs in the brain. Claudio Soto, PhD, director of The George and Cynthia Mitchell Center for Research in Alzheimer’s Disease and Related Brain Disorders at McGovern Medical School at UTHealth Houston, will serve as the lead principal investigator under the award.

Aligning Science Across Parkinson’s and The Michael J. Fox Foundation Expand Global Research Initiative with $261M Investment Toward Personalized Treatments

Aligning Science Across Parkinson’s and The Michael J. Fox Foundation Expand Global Research Initiative with $261M Investment Toward Personalized Treatments

04/28/2026 — Today, Aligning Science Across Parkinson’s (ASAP), in partnership with The Michael J. Fox Foundation for Parkinson’s Research (MJFF), announced $261 million in new grant funding for the Collaborative Research Network (CRN) to map the biological blueprint of Parkinson’s disease and build a standardized toolkit of global research resources that are needed to turn discoveries into treatments.

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