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Team Strittmatter
CLEAR-PD: Clearance via Lymphatics & Endocytic Alpha-Synuclein Receptors in Parkinson’s Disease
In Parkinson’s disease (PD), it is clear that the alpha-synuclein protein accumulates in specific neurons, thereby damaging them to cause neurological symptoms. Remarkably, misfolded forms of this alpha synuclein protein spread from one cell to another through the fluid spaces of the brain. Understanding how this extracellular alpha-synuclein is either removed from the brain or delivered to neurons is central to defining PD progression and provides opportunities to modify disease course. Our proposed work seeks molecular approaches to enhance clearance of alpha-synuclein out of the brain and to reduce its interactions with neurons and consequent toxicity, providing potential therapeutic benefit.
Tags
Alpha-synucleinDisease modificationDrug targets
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Members of the CRN work diligently to advance our understanding of Parkinson’s disease. Learn more about recent CRN discoveries and achievements.
