Le Zhang
Co-PI (Core Leadership)
Collaborating PI
Key Personnel
Yale University
Le Zhang is an Assistant Professor in the Department of Neurology at Yale School of Medicine. Le obtained her B.S. in Biological Science from Peking University and her Ph.D. in Molecular Biology and Biochemistry from the University of Hong Kong. Le had her postdoctoral trainings at the University of Pennsylvania and Harvard Medical School.
Teams
Themes
Tags
Drug targets
VPS13C
SYNJ1
Lysosomal dysfunction
Metabolism
Disease modification
PD heterogeneity: clearance
Neuro-immune interactions
Central Nervous System (CNS)
Autoimmunity
LRRK2
Alpha-synuclein
Gut-brain axis
Recent ASAP Preprints & Published Papers
Drug Repurposing for Parkinson's Disease: A Large-Scale Multi-Cohort Study
Background Progress in Parkinson's disease (PD) is hampered by two critical obstacles: the lack of disease-modifying drugs and the difficulty of identify individuals at early, prodromal disease stages for clinical trials. Methods We conducted a retrospective, multi-cohort study using data from the Mass General Brigham (MGB) Biobank for discovery and…
Inflamed Microglia like Macrophages in the Central Nervous System of Prodromal Parkinson′s Disease
We identified a pleocytosis in the CSF, most pronounced in patients with early PD. Single-cell RNAseq revealed increases in CSF-specific microglia-like macrophages expressing JAK-STAT and TNFα signaling signatures in prodromal PD, with a lack of T cell activation in the CSF. The CSF macrophages exhibited similar transcriptional profiles to dural…
