Background pattern of a brain with neural connections
Shawn Ferguson

Shawn Ferguson

Co-PI (Core Leadership)

Yale University

Dr. Ferguson earned his Ph.D in Neuroscience from Vanberbilt University in 2004 and subsequently pursued postdoctoral studies at Yale University. Both of these training experiences focused on specialized membrane trafficking mechanisms that support synaptic transmission between neurons. In 2010, he established his independent laboratory in the Department of Cell Biology at Yale School of Medicine which focuses on the intersection between fundamental cell biology questions and neurological disease mechanisms He currently holds the rank of Associate Professor (tenured) and has a secondary appointment in Neuroscience.

Teams

De Camilli

Themes

Circuitry and Brain-Body Interactions

Tags

Mouse Other Microscopy - optical In Vivo Ex Vivo

Recent ASAP Preprints & Published Papers

LRRK2, lysosome damage, and Parkinson’s disease

Limited understanding of regulatory mechanisms controlling LRRK2 kinase activity has hindered insights into both its normal biology and how its dysregulation contributes to Parkinson’s disease. Fortunately, recent years have yielded an increased understanding of how LRRK2 kinase activity is dynamically regulated by recruitment to endolysosomal membranes. Notably, multiple small GTPases…

Derailed degradation: LRRK2-dependent exocytosis in Parkinson’s disease

In this PNAS commentary, Shawn M. Ferguson discusses the implications of new data presented by Palumbos et al. regarding Parkinson's disease-associated gain-of-function LRRK2 mutations. These mutations are linked to a notable increase in neuronal exocytosis, specifically the release of extracellular vesicles. These vesicles are characterized by their enrichment in intraluminal…

Team De Camilli

Pietro De Camilli

Pietro De Camilli

Lead PI (Core Leadership)
Shawn Ferguson

Shawn Ferguson

Co-PI (Core Leadership)
Kallol Gupta

Kallol Gupta

Co-PI (Core Leadership)
Karin Reinisch

Karin Reinisch

Co-PI (Core Leadership)
Timothy Ryan

Timothy Ryan

Co-PI (Core Leadership)
Benjamin Johnson

Benjamin Johnson

Project Manager

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