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Team Tansey
Investigating the role of immune cell exhaustion (ICE) and biological immune aging (BIA) in PD risk and PD heterogeneity
Age is the greatest risk factor for idiopathic Parkinson’s Disease (iPD), yet the contribution of the aging immune system to PD has been underexplored (1). Our recent work revealed that PD-linked LRRK2 mutations trigger age-acquired immune cell exhaustion (ICE) detectable in peripheral myeloid cells of mice and humans with LRRK2-PD (2). We hypothesize that ICE also contributes to risk and heterogeneity of iPD. Our proposal will investigate the extent to which ICE develops as a function of age, at specific stages of iPD, how infections contribute to ICE, and if ICE is necessary and/or sufficient to induce brain PD-like pathology.
Tags
AgingBloodImmune responseInfection modelsInflammationLRRK2Lysosomal dysfunctionPeripheral immune systemSingle-cell multi-omics
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