In Parkinson’s disease (PD) there is a preferential dysfunction of specific brain circuits. Dopaminergic and noradrenergic circuit malfunction resulting from degeneration of subsets of substantia nigra (A9), ventral tegmental area (A10) and locus coeruleus (A6) pigmented neurons leads to motor and non-motor PD features and constitute the most robust clinico-pathological correlation associated with the disease. By combining multidisciplinary approaches across species, we will unravel molecular mechanisms linking brain circuit activity to PD vulnerability, identify brain circuits through which PD pathology spreads across the brain and periphery, and assess the contribution of non-neuronal mechanisms to PD progression.
Here is an overview of how this team’s article findings have contributed to the PD field as of June 2025. There are two different categorizations of these contributions – one by impact to the PD community and a second by scientific category.
Impact
Category
Members of the team have been recognized for their contributions.
Network Spotlights
Yuhong Fu, Ka Wai Lee
Awards
Updates will be posted when available.
Members of the CRN work diligently to advance our understanding of Parkinson’s disease. Learn more about recent CRN discoveries and achievements.
