Sonia Gandhi
Co-PI (Core Leadership)
University College London
Sonia is a Professor of Neurology at UCL, and a Group Leader at The Francis Crick Institute. She studied the role of PINK1 in autosomal recessive Parkinson’s during her PhD, and subsequently established her own laboratory studying the effects of alpha-synuclein oligomerisation in neurons. Her work focuses on the interaction between protein aggregation and mitochondrial dysfunction in human neurons.
Recent ASAP Preprints & Published Papers
The annotation of GBA1 has been concealed by its protein-coding pseudogene GBAP1
Mutations in GBA1 cause Gaucher disease and are the most important genetic risk factor for Parkinson’s disease. However, analysis of transcription at this locus is complicated by its highly homologous pseudogene, GBAP1. We show that >50% of short RNA-sequencing reads mapping to GBA1 also map to GBAP1. Thus, we used…
Network nature of ligand-receptor interactions underlies disease comorbidity in the brain
Neurodegenerative disorders have overlapping symptoms and have high comorbidity rates, but this is not reflected in overlaps of risk genes. We have investigated whether ligand-receptor interactions (LRIs) are a mechanism by which distinct genes associated with disease risk can impact overlapping outcomes. We found that LRIs are likely disrupted in…
