Nicholas Wood
Lead PI (Core Leadership)
University College London
Nick Wood is clinician scientist and professor of Neurology and Genetics at UCL London. He has worked in complex trait and single gene analyses since his graduate work in the genetics of multiple sclerosis at the University of Cambridge. He undertook post-doctoral work with Anita Harding at UCL Institute of Neurology. He has led the neurogenic service at the National Hospital Queen Square London since 1995. He was appointed to the Galton Chair of genetics at UCL in 2009.
Recent ASAP Preprints & Published Papers
Parkinson's Families Project: a UK-wide study of early onset and familial Parkinson's disease
The Parkinson’s Families Project is a UK-wide study aimed at identifying genetic variation associated with familial and early-onset Parkinson’s disease (PD). We recruited individuals with a clinical diagnosis of PD and age at motor symptom onset ≤ 45 years and/or a family history of PD in up to third-degree relatives.…
The annotation of GBA1 has been concealed by its protein-coding pseudogene GBAP1
Mutations in GBA1 cause Gaucher disease and are the most important genetic risk factor for Parkinson’s disease. However, analysis of transcription at this locus is complicated by its highly homologous pseudogene, GBAP1. We show that >50% of short RNA-sequencing reads mapping to GBA1 also map to GBAP1. Thus, we used…
