Background pattern of a brain with neural connections
Clemens Scherzer

Clemens Scherzer

Lead PI (Core Leadership)

Brigham & Women's Hospital

Clemens Scherzer, M.D. is Professor of Neurology at Harvard Medical School. He directs the Center for Advanced Parkinson Research and the Precision Neurology Program of Brigham & Women’s Hospital. Scherzer uses genomes and computation to develop a future, predictive and proactive health care for Parkinson’s and other common neurologic diseases. His is to match precision drugs and biomarkers to the genetic blueprint of individual patients and prevent disease from ever progressing. Scherzer co-founded the major biobanks for Parkinson’s disease, including the Harvard Biomarkers Study. He serves on the Scientific Advisory Board of the American Parkinson Disease Foundation and his work was featured in Science, Scientific American, Washington Post, US News & World Reports, and NOVA Next.

Teams

Scherzer

Themes

PD Functional Genomics

Tags

Protein purification Recombinant

Recent ASAP Preprints & Published Papers

Drug Repurposing for Parkinson's Disease: A Large-Scale Multi-Cohort Study

Background Progress in Parkinson's disease (PD) is hampered by two critical obstacles: the lack of disease-modifying drugs and the difficulty of identify individuals at early, prodromal disease stages for clinical trials. Methods We conducted a retrospective, multi-cohort study using data from the Mass General Brigham (MGB) Biobank for discovery and…

Experimental and Computational Methods for Allelic Imbalance Analysis from Single-Nucleus RNA-seq Data

Single-cell RNA-seq (scRNA-seq) is emerging as a powerful tool for understanding gene function across diverse cells. Recently, this has included the use of allele-specific expression (ASE) analysis to better understand how variation in the human genome affects RNA expression at the single-cell level. We reasoned that because intronic reads are…

Team Scherzer

Clemens Scherzer

Clemens Scherzer

Lead PI (Core Leadership)
Xianjun Dong

Xianjun Dong

Co-PI (Core Leadership)
Mel Feany

Mel Feany

Co-PI (Core Leadership)
Joshua Levin

Joshua Levin

Co-PI (Core Leadership)
Su-Chun Zhang

Su-Chun Zhang

Co-PI (Core Leadership)
Beatrice Weykopf

Beatrice Weykopf

Project Manager

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