Mel Feany
Co-PI (Core Leadership)
Brigham & Women's Hospital
Dr. Mel Feany is a Professor of Pathology at Brigham and Women’s Hospital and Harvard Medical School. She is a physician scientist with a Ph.D. in neurobiology and postgraduate medical training in pathology and neuropathology. Her favorite honor is the 2019 Landis Award for Outstanding Mentorship from the NINDS, which was supported by multiple former mentees who are current ASAP awardees.
Recent ASAP Preprints & Published Papers
Deep sequencing of proteotoxicity modifier genes uncovers a Presenilin-2/beta-amyloid-actin genetic risk module shared among alpha-synucleinopathies
Whether neurodegenerative diseases linked to misfolding of the same protein share genetic risk drivers or whether different protein-aggregation pathologies in neurodegeneration are mechanistically related remains uncertain. Conventional genetic analyses are underpowered to address these questions. Through careful selection of patients based on protein aggregation phenotype (rather than clinical diagnosis) we…
Pathways controlling neurotoxicity and proteostasis in mitochondrial complex I deficiency.
Neuromuscular disorders caused by dysfunction of the mitochondrial respiratory chain are common, severe and untreatable. We recovered a number of mitochondrial genes, including electron transport chain components, in a large forward genetic screen for mutations causing age-related neurodegeneration in the context of proteostasis dysfunction. We created a model of complex…
