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Team Goedert
Seeded aggregation of alpha-synuclein
Assembly of alpha-synuclein into filaments is central to Parkinson’s disease (PD), dementia with Lewy bodies (DLB) and multiple system atrophy (MSA). By cryo-EM we showed that filaments adopt the same Lewy fold in PD and DLB, with a different fold in MSA. This application aims to identify the molecular identities of non-proteinaceous densities, as well as the structures of alpha-synuclein filaments from additional inherited forms of PD and, as co-pathology from Alzheimer’s disease and progressive supranuclear palsy. We will also establish methods by which to study the mechanisms of seeded aggregation and characterise the alpha-synuclein filaments present following aqueous extraction.
Tags
A53TAlpha-synucleinConformational strainsCryo-EMFibrilGBA (Glucocerebrosidase)iPSC neuronsLewy bodiesLRRK2MSA (Multiple system atrophy)Protein aggregatesSeeding assays
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