Background pattern of a brain with neural connections
Yang Yang

Yang Yang

Co-PI (Core Leadership)

Collaborating PI

Van Andel Institute

Yang Yang is an Assistant Professor at the Van Andel Institute, where her research focuses on the structural biology of α-synuclein and its role in Parkinson’s disease and related synucleinopathies. Using cryo-EM, she has determined the structures of postmortem α-synuclein filaments. Her work has contributed to defining disease-relevant α-synuclein filament architectures and to understanding how molecular cofactors and co-pathologies influence aggregation and seeding. Her long-term goal is to link α-synuclein structures to disease mechanism, enabling structure-based approaches to diagnosis and therapy in synucleinopathies.

Teams

Themes

Tags

Fibril Alpha-synuclein Protein aggregates LRRK2 GBA (Glucocerebrosidase) Pathology Proteomics Cryo-EM Lewy bodies Seeding assays A53T Cryo-ET MSA (Multiple system atrophy) Fluid-based biomarkers iPSC neurons Conformational strains PD heterogeneity: alpha-synuclein seeding

Recent ASAP Preprints & Published Papers

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