Background pattern of a brain with neural connections

Team McDonough

Toward a Complete Toolkit: Generation, Validation, and Dissemination of High Quality iPSC Models for Emerging Targets in Parkinson’s Disease

2026-Present

Parkinson’s is a complex neurodegenerative disorder with both inherited and sporadic forms. Recent research has identified many new genes linked to the disease, but scientists lack good experimental models they can use for deeper investigations. To bridge this gap, we will generate and deeply validate human stem-cell-based models with specific gene edits for each new target. Researchers will then be able to study the impact of gene mutations on key characteristics of the brain cell types most affected by Parkinson’s. All cell models, data, and methods will be made widely available to accelerate mechanistic discovery and therapeutics development.

Tags
AstrocytesCell biologyCRISPRi dCas9Data sharingGliahiPSCs (Human induced pluripotent stem cells)ImagingiPSC neuronsiPSCs (Induced pluripotent stem cells)MicrogliaProteomicssingle cell RNA sequencing (scRNASeq)

Contributions

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Accolades

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In the News

Unraveling Parkinson's. Advancing Precision Medicine.

Aligning Science Across Parkinson’s and The Michael J. Fox Foundation Expand Global Research Initiative with $261M Investment Toward Personalized Treatments

04/28/2026 — Today, Aligning Science Across Parkinson’s (ASAP), in partnership with The Michael J. Fox Foundation for Parkinson’s Research (MJFF), announced $261 million in new grant funding for the Collaborative Research Network (CRN) to map the biological blueprint of Parkinson’s disease and build a standardized toolkit of global research resources that are needed to turn discoveries into treatments.

Our Research Teams

Members of the CRN work diligently to advance our understanding of Parkinson’s disease. Learn more about recent CRN discoveries and achievements.