Background pattern of a brain with neural connections
Valentina Fossati

Valentina Fossati

Co-PI (Core Leadership)

The Jackson Laboratory

Valentina is a Senior Research Investigator at the NYSCF | JAX collaborative, where her research focuses on glia-driven pathogenic mechanisms in PD, multiple sclerosis, Alzheimer’s disease, and other CNS disorders. She earned her undergraduate degree in Pharmaceutical Biotechnology and a PhD in Stem Cell Biology from the University of Bologna and completed postdoctoral training at Mount Sinai in New York. Valentina pioneered the development of human iPSC-derived glial cell models, establishing protocols for oligodendrocytes, astrocytes, microglia, and 3D organoid systems. She generated the first iPSC lines from individuals with progressive multiple sclerosis, led large-scale studies to uncover inflammatory glial phenotypes in MS and pioneered stem cell studies in Low Earth Orbit.

Teams

Themes

Tags

iPSCs (Induced pluripotent stem cells) hiPSCs (Human induced pluripotent stem cells) Proteomics Astrocytes Microglia Cell biology Imaging CRISPRi dCas9 Glia Data sharing iPSC neurons single cell RNA sequencing (scRNASeq)

Recent ASAP Preprints & Published Papers

This investigator is hard at work. Articles will be shared when they are available.

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