Weiyi Peng
Co-PI (Core Leadership)
University of Houston
Dr. Peng is an Assistant Professor in the Department of Biology and Biochemistry at the University of Houston (UH). She received her PhD in Baylor College of Medicine, Houston, TX in Immunology. She has explored the underlying mechanisms of immune responses, and has published a series of studies related to cancer and the immune system.
Recent ASAP Preprints & Published Papers
Soluble Immune Factor Profiles in Blood and CSF Associated with LRRK2 Mutations and Parkinson's Disease
**Background and Objectives**: Mutations in the Leucine-rich repeat kinase 2 (*LRRK2*) gene are one of the most common genetic causes of Parkinson's disease (PD) and are linked to immune dysregulation in both the central nervous system and periphery. However, peripheral and central profiles of soluble immune factors associated with *LRRK2* mutations and PD…
LRRK2 G2019S mutation suppresses differentiation of Th9 and Treg cells via JAK/STAT3
The Leucine-rich repeat kinase-2 (LRRK2) G2019S mutation, resulting in aberrantly enhanced kinase activity, is one of the well-recognized genetic risk factors in Parkinson's Disease (PD). Increased LRRK2 activity was also observed in immune cells from PD patients. Emerging results have also unveiled an upsurge in alpha-synuclein (alpha-syn)-specific CD4+ T cell…
