Background pattern of a brain with neural connections
Xiqun Chen

Xiqun Chen

Lead PI (Core Leadership)

Massachusetts General Hospital

Xiqun is an Assistant Professor of Neurology at Massachusetts General Hospital and Harvard Medical School. Dr. Chen received her medical and PhD degrees and residency training from Shanghai Medical College, Fudan University. She then completed her postdoctoral fellowship at Columbia University. Dr. Chen joined Massachusetts General Hospital and established her research program focusing on Parkinson’s – cancer associations as a basis for better understanding Parkinson’s disease through multiple disciplinary collaborations.

Teams

Chen

Themes

PD Functional Genomics

Tags

PI3KC3-C1 complex Structural biology Human Other Rab

Recent ASAP Preprints & Published Papers

Baseline α-synuclein seeding activity and disease progression in sporadic and genetic Parkinson's disease in the PPMI cohort

### Background α-Synuclein (α-syn) seed amplification assays (SAAs) have shown remarkable potential in diagnosing Parkinson's disease (PD). Using data from the Parkinson's Progression Markers Initiative (PPMI) cohort, we aimed to test whether baseline α-syn seeding activity and α-syn SAA kinetic parameters are associated with disease progression in sporadic PD, *LRRK2*-associated PD…

AutoMorphoTrack: An Automated Python Package for Organelle Morphology, Motility, and Colocalization Analysis in Live-Cell Imaging

Understanding the dynamics and interactions of intracellular organelles is critical for understanding the mechanisms of cellular homeostasis and disease. Here, we present AutoMorphoTrack, an open-source Python package for automated detection (optional thresholding), morphology classification, motility tracking, and colocalization analysis of mitochondria and lysosomes in live-cell imaging data. The package provides…

Team Chen

Xiqun Chen

Xiqun Chen

Lead PI (Core Leadership)
Timothy Chan

Timothy Chan

Co-PI (Core Leadership)
Weiyi Peng

Weiyi Peng

Co-PI (Core Leadership)
Michael Schwarzschild

Michael Schwarzschild

Co-PI (Core Leadership)
Jackson Schumacher

Jackson Schumacher

Project Manager

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