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Team Parisiadou
Age-related RNA oxidation and ribosomal dysfunction in Parkinson’s disease vulnerable dopamine neurons
Parkinson’s disease (PD) involves the loss of certain dopamine-producing brain cells, but why some cells die while others survive remains unclear. We hypothesize that age-related damage to the protein synthesis machinery plays a central role in PD pathogenesis. Our team will utilize human brain samples and cells, refined genetic mouse models, and advanced tools to determine how, when, and where cell specific damage to the protein synthesis machinery disrupts proteostasis and promotes selective neuron loss in PD. By examining age-related effects and exploring potential mitigating approaches, we seek to uncover new strategies to delay or prevent PD progression.
Tags
Alpha-synucleinDisease modelsGBA (Glucocerebrosidase)LRRK2Organoid
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