Chuyu Chen
Project Manager
Key Personnel
Northwestern University
Chuyu is a postdoc fellow in the department of Pharmacology, Northwestern University. She studied the pathologic mechanism of LRRK2 by generating a disease model as a graduate student. After joining Parisiadou’s lab, she is devoted to studying cell type specific LRRK2 dysfunction.
Teams
Themes
Tags
Motor symptoms
Alpha-synuclein
LRRK2
Dopamine neuron subtypes
GBA (Glucocerebrosidase)
Organoid
Disease models
Circuit dysfunction
PD heterogeneity: aging
Recent ASAP Preprints & Published Papers
Leucine-rich repeat kinase 2 impairs the release sites of Parkinson’s disease vulnerable dopamine axons
The end-stage pathology of Parkinson’s disease (PD) involves the loss of dopamine-producing neurons in the substantia nigra pars compacta (SNc). However, synaptic deregulation of these neurons begins much earlier. Understanding the mechanisms behind synaptic deficits is crucial for early therapeutic intervention, yet these remain largely unknown. In the SNc, different…
LRRK2 mediates haloperidol-induced changes in indirect pathway striatal projection neurons
Haloperidol is used to manage psychotic symptoms in several neurological disorders through mechanisms that involve antagonism of dopamine D2 receptors that are highly expressed in the striatum. Significant side effects of haloperidol, known as extrapyramidal symptoms, lead to motor deficits similar to those seen in Parkinson’s disease and present a…
