Background pattern of a brain with neural connections
Loukia Parisiadou

Loukia Parisiadou

Lead PI (Core Leadership)

Co-PI (Core Leadership)

Northwestern University

Loukia is an Assistant Professor in the Department of Pharmacology at Northwestern University, where her research focuses on the neuronal mechanisms that drive Parkinson’s disease. She completed her postdoctoral training at the National Institutes of Health during a pivotal period for Parkinson’s disease genetics. Her group employs advanced genetic mouse models to identify in vivo pathogenic pathways in neurons. Loukia has received the National Institutes of Health Excellence in Research and Supervision and Mentorship Award and has contributed to open science and scientific transparency as an eLife Ambassador.

Teams

Dombeck Parisiadou

Themes

Circuitry and Brain-Body Interactions PD Heterogeneity

Tags

PD heterogeneity: aging Motor symptoms Alpha-synuclein LRRK2 Dopamine neuron subtypes GBA (Glucocerebrosidase) Organoid Disease models Circuit dysfunction

Recent ASAP Preprints & Published Papers

Leucine-rich repeat kinase 2 impairs the release sites of Parkinson’s disease vulnerable dopamine axons

The end-stage pathology of Parkinson’s disease (PD) involves the loss of dopamine-producing neurons in the substantia nigra pars compacta (SNc). However, synaptic deregulation of these neurons begins much earlier. Understanding the mechanisms behind synaptic deficits is crucial for early therapeutic intervention, yet these remain largely unknown. In the SNc, different…

LRRK2 mediates haloperidol-induced changes in indirect pathway striatal projection neurons

Haloperidol is used to manage psychotic symptoms in several neurological disorders through mechanisms that involve antagonism of dopamine D2 receptors that are highly expressed in the striatum. Significant side effects of haloperidol, known as extrapyramidal symptoms, lead to motor deficits similar to those seen in Parkinson’s disease and present a…

Team Dombeck

Dan Dombeck

Dan Dombeck

Lead PI (Core Leadership)
Rajeshwar Awatramani

Rajeshwar Awatramani

Co-PI (Core Leadership)
Mark Bevan

Mark Bevan

Co-PI (Core Leadership)
Tom Hnasko

Tom Hnasko

Co-PI (Core Leadership)
Loukia Parisiadou

Loukia Parisiadou

Co-PI (Core Leadership)
Ellen Fruzyna

Ellen Fruzyna

Project Manager

Team Parisiadou

Loukia Parisiadou

Loukia Parisiadou

Lead PI (Core Leadership)
Daniel Arango

Daniel Arango

Co-PI (Core Leadership)
Mark Cookson

Mark Cookson

Co-PI (Core Leadership)
Elisa Greggio

Elisa Greggio

Co-PI (Core Leadership)
Sabine Hilfiker

Sabine Hilfiker

Co-PI (Core Leadership)
Chuyu Chen

Chuyu Chen

Project Manager
Amanda Schneeweis

Amanda Schneeweis

Data Manager

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