Background pattern of a brain with neural connections
Agnete Kirkeby

Agnete Kirkeby

Co-PI (Core Leadership)

University of Copenhagen

Agnete Kirkeby is an Associate Professor and group leader at the Novo Nordisk Foundation for Stem Cell Medicine (reNEW) at University of Copenhagen (Denmark) and at the Wallenberg Center for Molecular Medicine at Lund University (Sweden). The Kirkeby group has unique expertise in xenotransplantation and in using human pluripotent stem cells for production of subtype-specific human neurons, including also high-purity cultures of ventral midbrain dopamine neurons. This work has led to a European-based development of a stem cell treatment for Parkinson’s Disease (STEM-PD), which entered clinical trial in 2022 in Sweden (https://clinicaltrials.gov/ct2/show/NCT05635409). The group further produces various other different types of neurons and glial cells for use in regenerative therapy and disease modelling, and also studies early brain development using human stem cell and advanced microfluidic culturing techniques to model the developing human fetal neural tube.

Teams

Jakobsson

Themes

PD Functional Genomics

Tags

Mitophagy i3N-neurons

Recent ASAP Preprints & Published Papers

Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson’s disease

Parkinson’s disease (PD) is a common age-related neurodegenerative disorder involving a neuroinflammatory response, the cause of which remains unclear. Transposable elements (TE) have been linked to inflammatory states, but their potential role in PD has not been explored. Using bulk– and single nuclei RNAseq of postmortem brain tissue from four…

LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development

Long interspersed nuclear element 1 (L1) retrotransposons represent a vast source of divergent genetic information. However, mechanistic analysis of whether and how L1s contribute to human developmental programs is lacking, in part due to the challenges associated with specific profiling and manipulation of human L1 expression. Here we show that…

Team Jakobsson

Johan Jakobsson

Johan Jakobsson

Lead PI (Core Leadership)
Roger Barker

Roger Barker

Co-PI (Core Leadership)
Molly Gale Hammell

Molly Gale Hammell

Co-PI (Core Leadership)
Agnete Kirkeby

Agnete Kirkeby

Co-PI (Core Leadership)
Laura Castilla-Vallmanya

Laura Castilla-Vallmanya

Project Manager

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