Ayse Ulusoy
Lead PI (Core Leadership)
Key Personnel
German Center for Neurodegenerative Diseases
Ayse received her PhD in 2010 in Lund (Sweden). There, she gained expertise in developing animal models of neurodegeneration, particularly by designing and applying specific adeno-associated viral vectors in vivo to modulate disease-related gene expression in the dopaminergic system. Later, she worked at the German Center for Neurodegenerative Diseases, Bonn (Germany) as a post-doctoral researcher, where she expanded her research to investigate Parkinson’s disease pathology beyond the nigrostriatal system. Particularly, she is interested in elucidating mechanisms of alpha-synuclein spreading throughout the brain as well as in the peripheral nervous system. She is currently pursuing her research interests as a staff scientist at the German Center for Neurodegenerative Diseases, Bonn.
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Recent ASAP Preprints & Published Papers
Mitochondrial oxidant stress promotes α-synuclein aggregation and spreading in mice with mutated glucocerebrosidase
Post-fibrillization nitration of alpha-synuclein abolishes its seeding activity and pathology formation in primary neurons and in vivo