Laura Castilla-Vallmanya
Project Manager
Lund University
Laura is a postdoctoral researcher at Lund University (Sweden). She obtained her PhD in Genetics from University of Barcelona (Spain) and has a strong background in studying human genetic variation and rare neurodevelopment disorders.
Teams
Themes
Tags
Rab
PI3KC3-C1 complex
Structural biology
Human
Other
Recent ASAP Preprints & Published Papers
Activation of transposable elements is linked to a region- and cell-type-specific interferon response in Parkinson’s disease
Parkinson’s disease (PD) is a common age-related neurodegenerative disorder involving a neuroinflammatory response, the cause of which remains unclear. Transposable elements (TE) have been linked to inflammatory states, but their potential role in PD has not been explored. Using bulk– and single nuclei RNAseq of postmortem brain tissue from four…
LINE-1 retrotransposons mediate cis-acting transcriptional control in human pluripotent stem cells and regulate early brain development
Long interspersed nuclear element 1 (L1) retrotransposons represent a vast source of divergent genetic information. However, mechanistic analysis of whether and how L1s contribute to human developmental programs is lacking, in part due to the challenges associated with specific profiling and manipulation of human L1 expression. Here we show that…
