Background pattern of a brain with neural connections
Dario Alessi

Dario Alessi

Lead PI (Core Leadership)

University of Dundee

Professor Dario Alessi serves as the Director of the MRC Protein Phosphorylation and Ubiquitylation Unit at the University of Dundee. His research focuses on unravelling the roles of poorly characterised components which regulate human disease resulting from disruption of signalling networks. He has contributed to our understanding of several disease relevant signal transduction pathways including PDK1 (diabetes and cancer), LKB1 (cancer), WNKs (blood pressure). Much of Dario’s current work is focused on understanding LRRK2 and how mutations in this enzyme cause Parkinson’s disease.

Teams

Alessi

Themes

PD Functional Genomics

Tags

Ciliogenesis LRRK2 Lysosomes PINK1 Rab

Recent ASAP Preprints & Published Papers

Leucine-rich repeat kinase 2 impairs the release sites of Parkinson’s disease vulnerable dopamine axons

The end-stage pathology of Parkinson’s disease (PD) involves the loss of dopamine-producing neurons in the substantia nigra pars compacta (SNc). However, synaptic deregulation of these neurons begins much earlier. Understanding the mechanisms behind synaptic deficits is crucial for early therapeutic intervention, yet these remain largely unknown. In the SNc, different…

Leucine Rich Repeat Kinase 2: Pathways to Parkinson’s Disease

The past ten years have seen tremendous progress in our understanding of Leucine Rich Repeat Kinase 2 (LRRK2) and how mutations activate the kinase and trigger downstream pathology, contributing to Parkinson’s disease. A breakthrough came from the identification of key LRRK2 substrates—a subset of small GTPases called Rab proteins. Cryoelectron…

Team Alessi

Dario Alessi

Dario Alessi

Lead PI (Core Leadership)
Monther Abu-Remaileh

Monther Abu-Remaileh

Co-PI (Core Leadership)
Miratul Muqit

Miratul Muqit

Co-PI (Core Leadership)
Suzanne Pfeffer

Suzanne Pfeffer

Co-PI (Core Leadership)
Enrico Bagnoli

Enrico Bagnoli

Project Manager

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Members of the CRN work diligently to advance our understanding of Parkinson’s disease. Learn more about recent CRN discoveries and achievements.

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