Background pattern of a brain with neural connections
Sreeja Vijayan Nair

Sreeja Vijayan Nair

Project Manager

Key Personnel

Stanford University

Sreeja is a postdoctoral researcher in the Pfeffer lab at the Department of Biochemistry, Stanford University. She completed her graduate studies at IISER Thiruvananthapuram, Kerala, India. During her graduate research, she worked on regulators of the NF-kB signaling pathway and protein ubiquitination.

Teams

Alessi Pfeffer

Themes

PD Functional Genomics PD Heterogeneity

Tags

Rab GTPases Cell biology Neuroprotective/regenerative Lysosomal dysfunction Endolysosomal dysfunction LRRK2 pathway PD heterogeneity: clearance Ciliogenesis LRRK2 Lysosomes PINK1 Rab GBA (Glucocerebrosidase)

Recent ASAP Preprints & Published Papers

Lysosomal Glucocerebrosidase is needed for ciliary Hedgehog signaling: A convergent pathway to Parkinson’s disease

Parkinson’s disease is characterized by loss of dopamine neurons that project to the dorsal striatum, and mutations in *LRRK2* and *GBA1* are the most common genetic causes of familial Parkinson’s disease. Previously, we showed that pathogenic *LRRK2* mutations inhibit primary cilia formation in rare interneurons and astrocytes of the mouse and human dorsal striatum. This blocks…

Team Alessi

Dario Alessi

Dario Alessi

Lead PI (Core Leadership)
Monther Abu-Remaileh

Monther Abu-Remaileh

Co-PI (Core Leadership)
Miratul Muqit

Miratul Muqit

Co-PI (Core Leadership)
Suzanne Pfeffer

Suzanne Pfeffer

Co-PI (Core Leadership)
Enrico Bagnoli

Enrico Bagnoli

Project Manager

Team Pfeffer

Suzanne Pfeffer

Suzanne Pfeffer

Lead PI (Core Leadership)
Monther Abu-Remaileh

Monther Abu-Remaileh

Co-PI (Core Leadership)
Dario Alessi

Dario Alessi

Co-PI (Core Leadership)
Esther Sammler

Esther Sammler

Co-PI (Core Leadership)
Raja Sekhar Nirujogi

Raja Sekhar Nirujogi

Co-PI (Core Leadership)
Sreeja Vijayan Nair

Sreeja Vijayan Nair

Project Manager
Toan Khoi Quoc Phung

Toan Khoi Quoc Phung

Data Manager

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