Background pattern of a brain with neural connections
Le Zhang

Le Zhang, PhD

Co-PI (Core Leadership)

Key Personnel

Collaborating PI

Yale University

Le Zhang is an Assistant Professor in the Department of Neurology at Yale School of Medicine. Le obtained her B.S. in Biological Science from Peking University and her Ph.D. in Molecular Biology and Biochemistry from the University of Hong Kong. Le had her postdoctoral trainings at the University of Pennsylvania and Harvard Medical School.

Teams

De Camilli Hafler Strittmatter

Themes

Neuro-Immune Interactions PD Functional Genomics PD Heterogeneity

Tags

Gut-brain axis Alpha-synuclein LRRK2 Autoimmunity Central Nervous System (CNS) Neuro-immune interactions Lysosomal dysfunction SYNJ1 VPS13C Drug targets Metabolism Disease modification PD heterogeneity: clearance

Recent ASAP Preprints & Published Papers

Drug Repurposing for Parkinson's Disease: A Large-Scale Multi-Cohort Study

Background Progress in Parkinson's disease (PD) is hampered by two critical obstacles: the lack of disease-modifying drugs and the difficulty of identify individuals at early, prodromal disease stages for clinical trials. Methods We conducted a retrospective, multi-cohort study using data from the Mass General Brigham (MGB) Biobank for discovery and…

scNAT: a deep learning method for integrating paired single-cell RNA and T cell receptor sequencing profiles

Many deep learning-based methods have been proposed to handle complex single-cell data. Deep learning approaches may also prove useful to jointly analyze single-cell RNA sequencing (scRNA-seq) and single-cell T cell receptor sequencing (scTCR-seq) data for novel discoveries. We developed scNAT, a deep learning method that integrates paired scRNA-seq and scTCR-seq…

Team De Camilli

Pietro De Camilli

Pietro De Camilli

Lead PI (Core Leadership)
Shawn Ferguson

Shawn Ferguson

Co-PI (Core Leadership)
Kallol Gupta

Kallol Gupta

Co-PI (Core Leadership)
Karin Reinisch

Karin Reinisch

Co-PI (Core Leadership)
Timothy Ryan

Timothy Ryan

Co-PI (Core Leadership)
Benjamin Johnson

Benjamin Johnson

Project Manager

Team Hafler

David Hafler

David Hafler

Lead PI (Core Leadership)
Sreeganga Chandra

Sreeganga Chandra

Co-PI (Core Leadership)
Rui Chang

Rui Chang

Co-PI (Core Leadership)
Noah Palm

Noah Palm

Co-PI (Core Leadership)
Ramnik Xavier

Ramnik Xavier

Co-PI (Core Leadership)
Nicholas Buitrago-Pocasangre

Nicholas Buitrago-Pocasangre

Project Manager

Team Strittmatter

Stephen Strittmatter

Stephen Strittmatter

Lead PI (Core Leadership)
Jonathan Javitch

Jonathan Javitch

Co-PI (Core Leadership)
Colleen Niswender

Colleen Niswender

Co-PI (Core Leadership)
Eric Song

Eric Song

Co-PI (Core Leadership)
Le Zhang

Le Zhang

Co-PI (Core Leadership)
Li Fu

Li Fu

Project Manager, Data Manager

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