Christine Stadelmann
Co-PI (Core Leadership)
Collaborating PI
University Medical Center Göttingen, Germany
Christine is a Professor of Neuropathology at the University Medical Center Göttingen, Germany. She trained with Hans Lassmann, Kurt Jellinger, Wolfgang Brück and Andreas von Deimling focussing on mechanisms of cell death, oligodendrocyte pathology, and remyelination.
Teams
Themes
Tags
Hyposmia
Olfactory dysfunction
PD progression
Machine learning
Neurodegeneration
Proteostasis
Cryo-ET
Mitochondrial morphology
PD subtypes
Mitochondrial dysfunction
PD heterogeneity: co-pathology
PD heterogeneity: clearance
Transcriptomics
Olfaction
Proteomics
Brain
Alpha-synuclein
PINK1
Pathology
Recent ASAP Preprints & Published Papers
3D imaging of neuronal inclusions and protein aggregates in human neurodegeneration by multiscale x-ray phase-contrast tomography
This study leverages x-ray phase-contrast tomography (XPCT) for detailed analysis of neurodegenerative diseases, focusing on the three-dimensional (3D) visualization and quantification of neuropathological features within fixed human postmortem tissue. XPCT with synchrotron radiation offers micrometer and even sub-micron resolution, enabling us to examine intra- and extraneuronal aggregates and inclusions such…
Neuropathological assessment of the olfactory bulb and tract in individuals with COVID-19
The majority of patients with Parkinson disease (PD) experience a loss in their sense of smell and accumulate insoluble alpha-synuclein aggregates in their olfactory bulbs (OB). Subjects affected by a SARS-CoV-2-linked illness (COVID-19) frequently experience hyposmia. We previously hypothesized that alpha-synuclein and tau misprocessing could occur following host responses to…
